Abstract：Objective To evaluate the correlation between chest muscle area and chronic obstructive pulmonary disease (COPD) in
patients with COPD, and to determine the correlation between the size of the chest muscle area and the acute exacerbation period and
the body mass index of patients with COPD. Methods A total of 73 cases in ECLIPSE group were included in the study to evaluate
the association between the pectoralis major muscle and fat weight measurement. For COPD genetic group, a total of 966 COPD
subjects were included to analyze the correlation between the pectoralis major area and clinical characteristics. The area of chest
muscle was evaluated by the radiologists in a double blind. Results In the ECLIPSE group, the R2 correlation between the pectoralis
major muscle area and lean body weight was 0.76. COPD experimental group of pectoralis major area was lower than that of the
control group, with statistical significance in COPD genome. The entire experimental group had higher forced expiratory volume
(FEV1) and forced vital capacity (FVC). The FEV1/FVC ratio showed there was very little airway obstruction. After correction of
the age, gender, height and smoking history, the FEV1 predictive value of correlation was significantly increased by 0.81% (95%
CI 0.63-0.99, P<0.001) when the pectoralis major muscle area increased by 1 cm2. Correspondingly, the correlation of emphysema
decreased by 0.63% (95%CI -0.7-0.51, P<0.001). CT quantitative analysis was significantly associated with SGRQ score, SpO2
score, SGRQ level, 6 min walk distance, BODE index score, MMRC dyspnea score and disease exacerbation. Conclusion There is
correlation between the CT measurement of the cross-sectional area of the large chest muscle and the severity of COPD. Besides, the
measurement of the area of the chest muscle can predict the course and severity of acute exacerbation of COPD.
邹殿俊，许晓炜，朱晓龙，杨飞，李传贵，崔书君，朱月香. CT定量分析与慢性阻塞性肺疾病骨骼肌变化的相关性分析[J]. 中国医疗设备, 2017, 32(12): 99-102.
ZOU Dianjun, XU Xiaowei, ZHU Xiaolong, YANG Fei, LI Chuangui, CUI Shujun, ZHU Yuexiang. Correlation Analysis of CT Quantitative Analysis and Changes of Chest Muscle in COPD Patients. China Medical Devices, 2017, 32(12): 99-102.
