Abstract：Objective To explore the application value of quantitative analysis of dynamic blood flow in benign and malignant
diagnosis of breast masses and compare its advantages and disadvantages with traditional semi-quantitative blood flow richness
assessment method. Methods A total of 114 lumps in 99 women admitted to the General Hospital of the Northern Theater Command
were selected as the study subjects. The patients underwent color Doppler blood flow imaging before surgery. According to the Adler
grading standard, grade 0 and 1 were marked as lacking blood supply, and grade 2 and 3 were marked as rich blood supply. Dynamic
blood flow quantitative analysis was performed to obtain blood flow quantitative index Rc and Rt. The masses were divided into
benign group and malignant group according to pathological findings. Chi-square test was used for the comparison of counting data.
Two independent samples t-test (normal distribution) or nonparametric Mann-Whitney U test (skewness distribution) were used for
measurement data comparison. The receiver operating characteristic (ROC) was constructed by using MedCalc analysis software.
The area under ROC curve (AUC), 95%CI, optimum truncation value, sensitivity and specificity were obtained by using R language
package. Z-test was used to compare whether the differences between AUC were statistically significant. Results According to the
pathological results, there were 48 masses in the benign group and 66 masses in the malignant group. Blood flow indexes in the
benign group were 30 cases (62.50%) with poor blood supply, median Rc was 15.40%, median Rt was 6.10%. In the malignant group,
40 cases (60.61%) of blood flow Alder grading were rich blood supply, with a median Rc of 23.65% and A median Rt of 10.95%. The
AUC of Alder grading Rc and Rt was 0.66, 0.72 and 0.78, while the cut-off value was grade 2, 15.10% and 6.50%. The sensitivity
was 60.61%, 86.36%, 92.42%, and the specificity was 62.50%, 50.00%, 54.17%. There were statistically significant differences
between Rc, Rt and Alder grading AUC (P=0.03, P=0.04). Conclusion Dynamic blood flow quantitative analysis has certain value in
differentiating benign and malignant breast masses. Compared with traditional Alder grading semi-quantitative evaluation, dynamic
blood flow quantitative analysis has higher diagnostic efficiency.
张佳琦，曹军英. 动态血流定量分析在乳腺肿块良恶性
鉴别中的应用价值[J]. 中国医疗设备, 2023, 38(4): 91-95.
ZHANG Jiaqi, CAO Junying. Application Value of Quantitative Analysis of Dynamic Blood Flow in the Identification of
Benign and Malignant Breast Masses. China Medical Devices, 2023, 38(4): 91-95.
