Abstract：Objective To evaluate the function of left atrial appendage (LAA) in patients with non-valvular atrial fibrillation
(NVAF) by applying Two-Dimension ultrasonic Speckle Tracking Imaging (2D-STI), and provide a reference for predicting the
formation of LAA thrombus. Methods A total of 60 patients with atrial fibrillation were collected, including 31 patients in the left
atrial appendage without thrombosis group, 29 patients in the LAA group with thrombosis, and 30 patients in the normal control
group. The left atrial diameter (LAD) was measured using transthoracic echocardiography (TTE). The LAA images were collected
on transesophageal echocardiography (TEE), and the left atrial appendage diameter (LAA-D) was measured respectively. left atrial
appendage length (LAA-L), left atrial appendage peak blood flow emptying velocity (LAA-PEV), left atrium appendage emptying
fraction (LAA-EF), the left atrial appendage global longitudinal strain (LAA-GLS) was obtained using 2D STI, and the value of
each indicator in the evaluation of LAA function was analyzed. Results There were no significant differences between LAA-D and
LAA-L groups (P>0.05). LAA-GLS and LAA-EF in the no thrombus-free group were lower than those in the control
group (P<0.05). LAA-PEV, LAA-GLS and LAA-EF in the thrombosis group were lower than those in the control group, and LAD
was higher than those in the control group (P<0.05). LAA-PEV and LAA-GLS in the thrombus group were lower than those in the
non-thrombosis group (P<0.05). LAA-PEV, LAA-GLS and LAA-EF were correlated with CHA2DS2-VASC score (P<0.05), and r
was -0.664, -0.826, -0.723, respectively. ROC curve showed that LAA-GLS had the highest sensitivity (0.833) and specificity (0.850)
for quantitative evaluation of LAA function. When the cut-off point was 10.68 in patients with atrial fibrillation, the sensitivity and
specificity of predicting LAA thrombus were 0.806 and 0.690, respectively. Conclusion Transesophageal echocardiography 2D-STI
can quantitatively evaluate changes in left atrial appendage function, which is of great significance in predicting the thrombosis of
left atrial appendage and provides imaging basis for clinical medication and treatment.
薛娜，刘昕，穆维娜，吕冰. 二维斑点追踪成像技术评价非瓣膜性心房颤动患者左心耳功能的应用价值[J]. 中国医疗设备, 2021, 36(9): 74-78.
XUE Na, LIU Xin, MU Weina, LV Bing. Application Value of Two-Dimensional Speckle Tracking Imaging Technology in Evaluating
Left Atrial Appendage Function in Patients with Nonvalvular Atrial Fibrillation. China Medical Devices, 2021, 36(9): 74-78.