Study on Measurement Method and Platform of Electrical Impedance Characteristics of
Breast Cancer After Neoadjuvant Chemotherapy
WANG Ruiqing1,2，ZHANG Wei1，XU Fan2，SHI Xuetao2，LIU Benyuan2，JI Zhenyu2
1. Department of Medical Engineering, Hospital of the 82nd Group Amy of PLA, Baoding Hebei 071000, China丨
2. School of Military Biomedical Engineering, Air Force Military Medical University, Xi’an Shanxi 710032, China
Abstract：Objective To explore the method of measuring the electrical impedance characteristics of breast cancer tissue after
neoadjuvant chemotherapy (NAC), a measurement platform was established to provide a theoretical foundation for studying the
electrical impedance characteristics of breast cancer tissue after NAC. Methods A cylindrical measuring box with adjustable
capacity was designed, and a platform for measuring the electrical impedance characteristics of small biological tissue was
established based on the two-electrode method. Moreover, the accuracy and feasibility of the platform were verified by measuring
the electrical impedance characteristics of gradient concentration of NaCl solution with breast cancer and per-cancer tissues in
nude mice bearing breast cancer. Results In the measuring frequency band, when the measuring length was 5 mm, the relative
error between the conductivity of NaCl solution and the theoretical value was 8.2% at 0.01 mol/L, then decreased rapidly with
increasing of the concentration of NaCl solution, down to 1.7% at 0.09 mol/L, and finally tended to flatten. When the concentration
of NaCl solution was fixed, the relative errors were decreased gradually with the increase of sample length, but all within 5%. In the
measured frequency range, the electrical conductivity of cancer tissue was 2.2~9.4 times of that of peri-cancer tissue, and the relative
permittivity of cancer tissue was 3.0~6.3 times of that of peri-cancer tissue. Conclusion The established measurement platform can
attain the accurate measurement of electrical impedance characteristics of small biological tissues, which provides a platform and
method basis for the following study of tissue impedance characteristics of breast cancer after NAC.
王瑞青1,2，张伟1，徐帆2，史学涛2，刘本源2，季振宇2. 新辅助化疗后乳腺癌组织电阻抗特性测量方法及测量平台研究[J]. 中国医疗设备, 2021, 36(6): 40-44.
WANG Ruiqing1,2，ZHANG Wei1，XU Fan2，SHI Xuetao2，LIU Benyuan2，JI Zhenyu2. Study on Measurement Method and Platform of Electrical Impedance Characteristics of
Breast Cancer After Neoadjuvant Chemotherapy. China Medical Devices, 2021, 36(6): 40-44.
