Abstract:Objective To investigate the relationship between shear wave elasticity of breast lesions and the number of cells, the content of collagen fiber and the density of blood vessel in the lesions. Methods A total of 42 cases of patients with breast lesions
who underwent ultrasound-guided core needle biopsy, routine ultrasound examination and shear wave elastography were performed in all patients before surgery. All patients’ pathological specimens were underwent HE staining to make a pathological diagnosis
and count the number of cells. The specimens should also underwent Masson staining to calculate the area of collagen fibers, and immunohistochemical staining to calculate the expression level of VEGF. Results The maximum, average and minimum
elastic modulus of malignant lesions and the ratio of lesion to surrounding tissues were significantly higher than that of benign lesions. The number of cells of malignant lesions was (502.57±167.698), which was significantly less than that of benign lesions
(838.11±211.886) (P<0.05). The content of collagen fibers of malignant lesions was (70114.69±13678.26) μm2, which was significantly higher than that of benign lesions (47022.47±15051.32) μm2 (P<0.05). There was a negative correlation between
maximum elasticity and the the number of cells (r=-0.630, P<0.05), and a positive correlation between maximum elasticity and the content of fiber collagen (r=0.646, P<0.05). In 23 malignant lesions, the positive expression rate of VEGF was 82.61% (19/23),
and in 19 benign lesions, the positive expression rate of VEGF was 15.8% (3/19). The expression of VEGF in malignant lesions was significantly higher than that in benign lesions (P<0.05), but there was no obvious correlation with the shear wave elasticity.
Conclusion Shear wave elasticity of breast lesions has a close correlation with the content of collagen fibers in lesions.
廉祎,黄瑛. 乳腺病变剪切波弹性模量与病理基础的相关性研究[J]. 中国医疗设备, 2021, 36(1): 83-86.
LIAN Yi, HUANG Ying. Correlation between Shear Wave Elastic Modulus and Pathological Basis of Breast Lesions. China Medical Devices, 2021, 36(1): 83-86.