目的 探讨基于经验模式分解的心肺耦合分析技术（Cardio-Pulmonary Coupling，HHT-CPC）对儿童睡眠呼吸紊乱 （Sleep-Disordered Breathing，SDB）的诊断价值。方法 回顾性分析整夜Hypno PTT监测的儿童患者数据63例，根据鼻气流呼 吸紊乱指数（Respiratory Disturbance Index，RDI）区分不同严重程度SDB组。比较各组的Hypno PTT睡眠参数、OSA-18量表 评分及心肺耦合指标，观察新方法与临床SDB诊断方法的相关性与一致性；应用ROC曲线评价HHT-CPC的SDB诊断效率。结 果 疾病程度增加导致HHT-CPC的低频耦合、升高式低频耦合指标显著升高，而高频耦合明显降低，这些指标与Hypno PTT睡 眠呼吸参数均体现出较强的相关性。其中HHT-CPC的RDI与Hypno PTT的RDI、3%氧减指数的相关性最强（r=0.844和0.770， P<0.001），且Bland-Altman分析结果体现出较高的一致性。在疾病诊断方面，ROC曲线下面积0.93，敏感度与特异度分别为 0.85和0.90。结论 HHT-CPC与Hypno PTT诊断儿童SDB具有较好的一致性，具有较高的诊断价值。

Objective To explore the diagnostic value of empirical mode decomposition-based cardio-pulmonary coupling (HHT-CPC) technique in pediatric sleep-disordered breathing (SDB). Methods A total of 63 pediatric patients undergoing diagnostic overnight Hypno PTT were retrospectively analyzed and classified into severity and non-severity groups according to the nasal flow-derived respiratory disturbance index (RDI). Hypno PTT sleep parameters, OAS-18 scale scores and CPC indexes of each group were compared, and the correlation and consistency between HHT-CPC and Hypno PTT were observed in the diagnosis of clinical SDB. ROC curve was applied to evaluate SDB diagnostic efficiency of HHT-CPC. Results Patients in severity group presented increased low frequency coupling (LFC) and elevated LFC, but decreased high frequency coupling (HFC) compared to that of non-severity group. These HHT-CPC indices were strongly correlated with Hypno PTT parameters. Especially, the HHT-CPC based respiratory disturbance index (H-RDI) was strongly correlated with Hypno PTT based RDI and 3% oxygen desaturation index, where r=0.844 and 0.770 respectively, both P<0.001. Furthermore, Bland-Altman result showed high consistency between two methods. For SDB diagnosis, the area under ROC curve was 0.93, and the sensitivity and specificity were 0.85 and 0.90, respectively. Conclusion HHT-CPC and Hypno PTT have good consistency in the diagnosis of SDB in children, and have high diagnostic value.