Abstract:Objective To explore the effect of three parotid gland zoning delineation methods on the target area and parotid gland
dose in the intensity modulated radiotherapy plan for nasopharyngeal carcinoma. Methods A total of 4 patients with nasopharyngeal
carcinoma (T2N2M0, stage III) were selected, and each patient was prepared with 4 groups of intensity modulated radiotherapy plan
(plan 0, plan 1, plan 2, plan 3). Except for the parotid gland, the prescribed dose in the target area and the restricted dose of other
organs at risk were the same. The target area and organ at risk dose, especially parotid dose, were evaluated in 4 groups. Results All
the plans in the 4 groups met the dose limitation requirements of the target area and normal tissue. The Dmean of both sides of parotid
gland in the parotid gland delineation group (plan 1, 2, 3) was lower than that in the parotid gland delineation group (plan 0). Plan
2 both sides of the parotid gland Dmean<30 Gy, D50<26 Gy, were lower than plan 0, and could minimize the left and right side of the
parotid gland Dmean and D50. Conclusion Under the premise of meeting the dosage requirements of target and OARs, split-parotid
delineation by approach 2 is likely to minimize Dmean and D50 of parotid gland significantly. Whether the delineation approach can
reduce the radiation-induced parotid gland function damage is worth further research.
赵彬,青东,朱红蕾,马代远. 腮腺分区勾画方式对鼻咽癌IMRT计划靶区及腮腺剂量的影响[J]. 中国医疗设备, 2019, 34(3): 72-77.
ZHAO Bin, QING Dong, ZHU Honglei, MA Daiyuan. Effect of Split-Parotid Delineation Approaches on Target and Parotid
Gland of IMRT in Patients with Nasopharyngeal Carcinoma. China Medical Devices, 2019, 34(3): 72-77.