Effects of Portable Oxygen-Enriched Machine on Blood Indices of Rats
Under Simulated Chronic Hypoxic Environment
DONG Xu1,2, LEI Tao1, LUO Erping1
1.Faculty of Biomedical Engineering, The Fourth Military Medical University, Xi’an Shaanxi 710032, China;
2.Section of Research and Training, Department of Medical Affairs, Qingdao First Sanatorium, People’s Liberation Army Navy,
Qingdao Shandong 266071, China
Abstract：Objective To evaluate the application performance of portable oxygen-enriched machine by studying the effects of
portable oxygen-enriched machine on blood indices of rats under simulated chronic hypoxic environment. Methods Chronic hypoxic
environment was simulated by small hypobaric chamber and oxygen-enriched rooms were established by portable oxygen-enriched
machines and individually ventilated cages. 36 male Sprague-Dawley rats were randomly divided into 3 groups: normal control group
(NC group), high altitude hypoxia group (HH group) and high altitude oxygen enrichment group (HO group). Rats of HH group and
HO group were fed in the small hypobaric chamber for 4 weeks (22 h every day) and the rats of HO group also were fed in oxygenenriched
rooms for 8 hours every day. Rats of NC group were fed outside of the chamber at the same time. The blood indices of rats
were measured after 4 weeks. Results No statistical differences were found in the level of WBC of 3 groups (P>0.05). But compared
with NC group and HO group, the levels of RBC, Hb, HCT, MCV and MCH of HH group were significantly increased (P<0.05 or
P<0.01), and no statistical difference was found between NC group and HO group (P>0.05). Conclusion Portable oxygen-enriched
machine can enhance adaptive ability of rats by reducing level of RBC and improving functional reserve of blood system under
simulated chronic hypoxic environment.
董旭1,2，雷涛1，罗二平1. 便携式膜法氧气机在模拟高原慢性缺氧环境下对大鼠血液指标的影响[J]. 中国医疗设备, 2017, 32(12): 60-62.
DONG Xu1,2, LEI Tao1, LUO Erping1. Effects of Portable Oxygen-Enriched Machine on Blood Indices of Rats
Under Simulated Chronic Hypoxic Environment. China Medical Devices, 2017, 32(12): 60-62.
