Application Value of High Frequency Ultrasound Combined with High-
Sensitive C-Reactive Protein and Erythrocyte Sedimentation Rate in Involved
Metacarpophalangeal Joints of Early Rheumatoid Arthritis Patients
WANG Liang-liang1a, LI Juan1b,
GUO Xiao-wei2,
ZHAO Tong-hang1c,
SHI Pu-jun1d, LIN Li1e
1. a.Department of Ultrasonography; b.
Department
of Special Clinical; c. Department
of Anesthesiology; d. Department of
Equipment; e. Department of Obstetrics and
Gynecology, Liaocheng People’s Hospital,
Liaocheng Shandong 252000,China;2.
Department of Ultrasonography,Xiaoyi
People’s Hospital, Xiaoyi Shanxi 032300,
China
Abstract：Objective To examine metacarpophalangeal joints through the combination of high frequency
ultrasound technology, high-sensitive C-reactive protein (hs-CRP) as well as erythrocyte sedimentation
rate (ESR), and discuss their application value in the diagnosis of involved metacarpophalangeal joints
of patients with early rheumatoid arthritis (RA). Methods 36 cases of early RA patients with involving
metacarpophalangeal joints were selected as observation group, 50 cases of early RA patients without
involving metacarpophalangeal joints as positive control group and 50 cases of healthy subjects as
healthy control group. All patients were examined by high frequency ultrasound to measure synovial
thickening and vascular proliferation in synovium, also detected through hs-CRP and ESR. Results
The change of synovium and synovial vascular proliferation among the 3 groups were significantly
different (P<0.05). The hs-CRP concentration of patients with rich vascular proliferation at (8.34±6.05)
mg/L in observation group, was significantly higher compared with that of patients without obvious
vascular proliferation at (5.56±2.84) mg/L in positive control group as well as healthy subjects at
(2.36±0.78) mg/L in healthy control group (P<0.05). The ESR of (20.1±6.1) mm/H in observation group
was apparently higher than that of (8.3±2.4) mm/H in healthy control group (P<0.05). Conclusion
High frequency ultrasound technology could effectively detect the synovial thickness and vascular
proliferation, which was significant to early diagnosing RA. The hs-CRP had an important value in the
clinical diagnosis of early RA with involving metacarpophalangeal joints. The ESR played an important
role in auxiliary examining early RA. High frequency ultrasound technology combined with hs-CRP
and ESR was of important application value in the early clinical diagnosis of early RA with involving
metacarpophalangeal joints.
王亮亮1a，李娟1b，郭小维2，
赵同航1c，史朴军1d，林丽1e. 高频超声联合C反应蛋白及血沉在累及掌指关节的早期类风湿性关节炎的应用价值[J]. 中国医疗设备, 2017, 32(2): 65-67.
WANG Liang-liang1a, LI Juan1b,
GUO Xiao-wei2,
ZHAO Tong-hang1c,
SHI Pu-jun1d, LIN Li1e. Application Value of High Frequency Ultrasound Combined with High-
Sensitive C-Reactive Protein and Erythrocyte Sedimentation Rate in Involved
Metacarpophalangeal Joints of Early Rheumatoid Arthritis Patients. China Medical Devices, 2017, 32(2): 65-67.
