Evaluation of Hemostatic Performance of Cellulose Absorbable Hemostatic Materials with
Different Materials and Morphologies
GUO Xin1a,2, LIU Minsheng1a, NAN Chengrui1a, SHI Yunpeng1a, DONG Chao1b, ZONG Huiqian1b, ZHAO Zongmao1a
1. a. Department of Neurosurgery; b. Department of Medical Equipment, The Second Hospital of Hebei Medical University,
Shijiazhuang Hebei 050000, China; 2. Department of Neurosurgery, Xingtai Third Hospital, Xingtai Hebei 054000, China
Abstract：Objective To compare the hemostatic performance of cellulose absorbable hemostatic materials with different materials
and morphologies. Methods In vitro coagulation test: gauze hemostatic material was divided into carboxymethyl oxidized
regenerated cellulose group, hydroxyethyl cellulose (HEC) group, carboxyl oxidized regenerated cellulose (CORC) group and control
group (common gauze group) according to the materials. CORC was divided into gauze group, fiber group, non-woven group and
control group (common gauze group) according to the morphology of CORC materials. Whole blood of SD rats was used for in
vitro coagulation experiment, and the optical density (OD) of each group at 540 nm was measured. Animal experiments: hemostatic
materials were divided into HEC group, CORC group and control group according to the shape of gauze. CORC materials were
divided into gauze group, fiber group and control group according to the shape. The hemostatic time of materials in each group on
the rat brain injury model (T) and the quality difference before and after the experiment (W) were recorded. Results For the in
vitro coagulation test, the OD value of each experimental group was lower than that of the control group (P<0.05). There was no
significant difference in OD values of gauze morphology among all groups experimental (P>0.05). The OD values of fibril group and
non-woven group were lower than those of gauze group (P<0.05), but there was no significant difference between fibril group and
non-woven group (P>0.05). In animal experiment, T and W were decreased in all experimental groups compared with control group
(P<0.05). There was no significant difference between T and W in the experimental groups of gauze morphology (P>0.05). Compared
with gauze group, T and W in fiber group were decreased (P<0.05). Conclusion Cellulose absorbable hemostatic materials can
promote hemostasis. There is no significant difference in hemostatic performance between cellulose absorbable hemostatic materials
of different gauze forms. The hemostatic performance of CORC absorbable hemostatic materials in non-woven form is better than
that in gauze morphology.
郭鑫1a,2，刘民生1a，南成睿1a，石云鹏1a，董超1b，宗会迁1b，赵宗茂1a. 不同材质及形态的纤维素类可吸收止血材料的止血性能评价[J]. 中国医疗设备, 2023, 38(2): 126-130.
GUO Xin1a,2, LIU Minsheng1a, NAN Chengrui1a, SHI Yunpeng1a, DONG Chao1b, ZONG Huiqian1b, ZHAO Zongmao1a. Evaluation of Hemostatic Performance of Cellulose Absorbable Hemostatic Materials with
Different Materials and Morphologies. China Medical Devices, 2023, 38(2): 126-130.
