Abstract：Objective To explore the clinical application of acoustic densitometry (AD) in assessing heart damage induced by chest radiotherapy in patients with thoracic tumors. Methods Altogether 120 patients received chest radiotherapy were examined by echocardiography and acoustic densitometry before radiotherapy and six months later. Additionally, 29 healthy volunteers were enrolled as control group. Results Some abnormal echocardiography characters appeared in 15 patients after chest radiotherapy (12.5%). AD showed that integrated back-scatter (IBS) and IBS% was significantly higher; while cyclic variation of IBS (CVIB) and CVIB% were significantly lower than those obtained before irradiation. Among patients received combination of radiotherapy and anthracyclines treatment, the changes of parameters acquired from AD differed significantly from those patients treated by simplex irradiation or combination of radiotherapy and other chemotherapeutic drugs. At the same time, those data in patients received combination of radiotherapy and other chemotherapeutic drugs differed significantly from those patients treated by simplex irradiation. As to the control group, all of the parameters changed insignificantly six month later. Conclusion Echocardiography and AD can be used in assessing early heart damages induced by chest radiotherapy. Compared with echocardiography, AD was more sensitive in detecting microcosmic changes and abnormalities of heart functions. Combination of radiotherapy and anthracyclines or other chemotherapeutic drugs can aggravate the heart damage.
侯海燕. 声学密度定量技术在胸部放疗致心脏损害评价中的应用[J]. 中国医疗设备, 2015, 30(9): 108-111.
HOU Hai-yan. Assessment of Heart Damage Induced by Chest Radiotherapy with Acoustic Densitometry. China Medical Devices, 2015, 30(9): 108-111.
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