Meta Analysis of the Effect of Chlorhexidine Gluconate Antibacterial Dressing in
Preventing Central Venous Catheter-Related Bloodstream Infection
LIU Guangdi1a,2, LIU Yiwen1b,2, TIAN Yongming1b,2, TANG Li1a,2
1. a. Department of Respiratory and Critical Care Medicine; b. Department of Critical Care Medicine, West China Hospital, Sichuan
University, Chengdu Sichuan 610041, China; 2. West China School of Nursing, Sichuan University, Chengdu Sichuan 610041, China
Abstract：Objective To systematically evaluate the efficacy of chlorhexidine gluconate antibacterial dressing in the prevention of
central venous catheter-related bloodstream infections. Methods Through PubMed, Web of Science, Embase, Cochrane Library,
CNKI, China Biomedical Literature Database, Wanfang and other Chinese and English databases, we searched for randomized
controlled literature on the prevention of catheter-related venous bloodstream infections with chlorhexidine gluconate antibacterial
dressings. The retrieval time limit was from the establishment of the database to August 10, 2021. Two researchers independently
included qualified literature, extracted literature information and quality evaluation in accordance with the set inclusion and exclusion
criteria, and used RevMan 5.4 software for Meta analysis. Results A total of 12 Chinese and English literatures were included,
including 8773 patients. Meta analysis results showed that compared with ordinary dressings placed at the catheter puncture point,
chlorhexidine gluconate antibacterial dressings could effectively reduce the incidence of catheter-related venous bloodstream
infections (RR=0.47, 95%CI: 0.35-0.63). It could reduce the incidence of bacterial colonization in patients with catheters (RR=0.49,
95%CI: 0.32-0.57). Subgroup analysis found that there was no statistically significant difference between the subgroups, indicating
that chlorhexidine antibacterial dressings could reduce the occurrence of related venous bloodstream infections.
Conclusion Compared with ordinary dressings covering catheter puncture points, chlorhexidine gluconate antibacterial dressing can
effectively reduce the incidence of catheter-related venous bloodstream infection and the incidence of catheter bacterial colonization.
刘光娣1a,2，刘逸文1b,2，田永明1b,2，唐荔1a,2. 葡萄糖酸氯己定抗菌敷料预防中心静脉导管相关性血流感染效果的Meta分析[J]. 中国医疗设备, 2022, 37(5): 114-118.
LIU Guangdi1a,2, LIU Yiwen1b,2, TIAN Yongming1b,2, TANG Li1a,2. Meta Analysis of the Effect of Chlorhexidine Gluconate Antibacterial Dressing in
Preventing Central Venous Catheter-Related Bloodstream Infection. China Medical Devices, 2022, 37(5): 114-118.
