Abstract：The obstructive sleep apnea syndrome (OSAS) is a sleep apnea caused by repeated airway collapses. Anatomical abnormalities of the upper airway and related lesions have become the main cause of the disease. Considering the complex anatomy structure of the upper airway, many researchers in china and abroad utilize the medical imaging techniques and apply the methodology of bio-mechanics to analyze the various mechanisms of OSAS, so as to explore an effective treatment. This paper briefly introduces the background and recent progress in studies on the OSAS-related bio-mechanical behavior of the upper airway. Several main research methods are introduced, and the characteristic and future development of different methods are also analyzed and discussed.
YoKoyama M,Yamanaka N,Ishii H,et al.Evaluation of the Pharyngeal airway in obstructive sleep apnea:study by ultra-fast MR imaging[J].Aeta Otolaryngology Suppl,1996,523(2):242-244.
Strollo PJ Jr,Soose RJ,Maurer JT,et al.Upper-airway stimulation for obstructive sleep apnea[J].New England Journal of Medicine,2014,370(2):139-149.
Fietze I,Penzel T,Alonderis A,et al.Management of obstructive sleep apnea in Europe[J].Sleep Med,2011,12(2):190-197.
Qaseem A,Holty JE,Owens DK,et al.Management of obstructive sleep apnea in adults:a clinical practice guideline from the american college of physicians[J].Ann Intern Med,2013.
Frederick CB,Lomax LG,Black KA,et al.Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors[J].Toxicol Appl Pharmacology,2002,183(1):23-40.
Suto Y,Inoue Y.Examination of Pharyngeal obstruction with high speed MR and polysomnography[J].Aeta Radial,1996,37(3 Pt 1):315-320.
Lam B,Sam K,Mok WY,et al.Randomized study of three non-surgical treatments in mild to moderate obstructive sleep apnea[J].Thorax,2007,62(4):354-359.
Horschler I,Brücker Ch,Schroder W,et al.Investigation of the impact of the geometry on the nose flow[J].European Journal of Mechanics-B/Fluids,2006,25(4):471-490.