摘要CEM43 thermal dose is a very common concept in thermal oncology. Thermal dose is
the maximum amount of energy that can be transmitted during hyperthermia therapy conducted on
temperature-sensitive tissue. Thermal dose is also the maximum value of local energy accumulation in
human bodies, which can lead to tissue injury and pain. Thermal dose can also decrease the finishing
temperature and reduce the energy to the tolerable range. There are two functions of the individualized
hyperthermia treatment plan: it determines the setting and location that can realize the best tumor
hyperthermia therapy; at the same time, it can decrease the effect of hyperthermia therapy on healthy
tissues. There are four steps in the treatment plan of hyperthermia therapy for tumors: the first step is to
establish a three dimensional human body model and its corresponding an atomical structure that can be
used in numerical algorithm via medical imaging resources; the second step is to determine the volume
of the electromagnetic energy accumulation. Based on the peculiarity of frequency and materials, even
full-wave electromagnetic wave or quasi-static technique can be used to determine the tissue distribution.
Evaluation of the therapy can be conducted based on thermal dose and the corresponding tissue damage
model; the third step is to use Arrhenius model to provide direct evaluation of tissues in the thermal
ablation zone, solidification zone, as well as the necrotic area; the last step is the optimization of the
treatment plan.