Abstract：Objective To provide reference criteria for early diagnosis of Alzheimer’s disease (AD) by researching the resting-state functional MRI features of Alzheimer’s disease. Methods 17 AD patients and 17 healthy controls were examined with the resting-state fMRI using Siemens Magnetom TrioTim 3.0T MR scanner. The data was pre-processed through Matlab7.8, DPARSFA, SPM8 and Rest software package to acquire regional homogeneity maps in whole brain. Single sample t-test and group independent samples t-test were conducted, thus, the discrepant brain regions were found. Results Compared with normal controls, ReHo value of AD patients were elevated in right cerebellum posterior lobe, right inferior temporal gyrus, left cuneus, right thalamus, right postcentral gyrus, right inferior frontal gyrus, right parietal lobe, left caudate nucleus and left middle frontal gyrus, and were decreased in right middle frontal gyrus, right inferior temporal lobe, left putamen, right superior frontal gyrus, right posterior cingulate gyrus, right inferior parietal lobule, left middle temporal gyrus, left middle frontal gyrus and left anterior cingulate gyrus. Conclusion Compared with normal aging group, there is localized resting-state brain region dysfunction in AD patients, which is of great significance for the early diagnosis of AD.
李辉，陶磊，倪萍，聂玫，吴清清，吴玉珍，陈自谦. 阿尔茨海默病患者静息态功能磁共振研究[J]. 中国医疗设备, 2014, 29(11): 15-18.
LI Hui, TAO Lei, NI Ping, NIE Mei, WU Qing-qing, WU Yu-zhen, CHEN Zi-qian. Resting-State Functional Magnetic Resonance Imaging Study of Alzheimer’s Patients. China Medical Devices, 2014, 29(11): 15-18.
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