Abstract：Pathologies and vascular forms of most biological tissues are closely associated with the changes of tissue microcirculations. Optical coherence tomography (OCT) is an imaging technique capable of providing non-invasive three-dimensional (3D) images of tissue microstructure with cellular level resolution. As a recent technological extension to OCT, optical microangiography (OMAG) is a volumetric imaging technique that is capable of producing 3D images of dynamic blood perfusion within microcirculatory tissue beds in vivo. OMAG is of high spatial resolution that is sufficient to delineate single capillary vessels, and does not require the use of contrast agents. The OMAG imaging contrast is based on the intrinsic optical scattering signals backscattered by moving blood cells in patent blood vessels. In this paper, I will first provide a brief review of the OMAG theory, and then present some examples of using OMAG to delineate the dynamic blood perfusion, down to capillary level resolution, within living tissues, including brain, skin, and retina.
王瑞康. 在体组织微循环的无标记光学微血管造影[J]. 中国医疗设备, 2013, 28(11): 1-4.
Ruikang K Wang. Label Free Optical Microangiography of Tissue Microcirculations in Vivo. China Medical Devices, 2013, 28(11): 1-4.
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