Abstract：Objective To investigate the effect of modified ultrafiltration (MUF) on lung functions of patients after cardiac valve replacement. Methods 60 patients who would undergo cardiac valve replacement were randomly divided into M (modified ultrafiltration) group (n=30) and C (control) group (n=30). Parameters including haematocrit (HCT), oxygenation index (OI) and alveolar-arterial oxygen tension gradient (P(A-a)O2) of patients before cardiopulmonary bypass (CPB) were monitored, and those parameters of patients before and after modified ultrafiltration were also monitored. The mechanical ventilation time and ICU supervision time of patients after cardiac valve replacement in the two groups were also recorded. Results HCT of patients at pre-MUF was obvious lower than that at pre-CPB (P<0.05), and HCT of patients at post-MUF was obvious higher than that at pre–MUF (P<0.05) while was still lower than that at pre-CPB (P<0.05) in M group. The mechanical ventilation time and ICU supervision time of patients in M group were obvious shorter than that in C group (P<0.05). OI of patients at post-MUF in M group was obvious higher than that in C group (P<0.05). P(A-a)O2 of patients at post-MUF in M group was obvious lower than that in C group (P<0.05). Conclusion The application of modified ultrafiltration in cardiopulmonary bypass in cardiac valve replacement can decrease postoperative edemata and inflammation reactions, which is beneficial to the recovery of pulmonary functions.
Gaynor JW.The effect of modified ultrafiltration on the postoperative course in patients with congenital heart disease[J].
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