1. Department of Radiotherapy, Chinese PLA General Hospital, Beijing 100853, China丨
2. Department of Radiotherapy, The Army Force Medical Center of PLA, Beijing 100142, China
Abstract：Objective To explore the safety and advantages of different radiotherapy techniques by comparing the differences in
dosimetry and incidence of radiotherapy-induced oral mucositis between volume-modulated arc radiotherapy (VMAT) and helical
tomotherapy (HT) plans in patients with oropharyngeal carcinoma. Methods A total of 22 patients with oropharyngeal carcinoma
who underwent VMAT and HT from June 2016 to June 2018 were respectively selected, and there was no difference in clinical data
between the two groups. The D1%, D5%, D95%, D99% and D99%, conformity index (CI) of the target volume, homogeneity index (HI) of
the target volume, and the volume of oral cavity, Dmax, Dmin, Dmean, V15, V20, V25, V30, V35, V40, V45, V50, V55, V60 were evaluated between
the two groups according to the dose-volume histogram. The incidence and severity of radiotherapy-induced oral mucositis were also
observed. Results The D99% of pGTVnx, PTV1 and PTV2 in the HT group were higher than those in the VAMT group (F=4.328, 2.875,
3.765, P<0.05), and the CI was closer to 1 (F=-2.245, -1.986, -1.867, P<0.05)丨 but there was no statistically difference in D1%, D5%,
D95% and HI of the target area (P>0.05). The Dmin of the oral cavity in the HT group was greater than that of the VMAT group (95%CI:
0.001~0.003, P<0.05), and V35 was significantly lower than that of VMAT group (95%CI: 0.042~0.057, P<0.05)丨 but there was no
statistically difference in V15, V20, V25, V30, V35, V40, V45, V50, V55, V60 of the oral cavity (P>0.05). The treatment time of the HT group
was longer than that of the VMAT group (F=7.672, P=0.009)丨 however, the incidence of ≥3 grade oral mucositis was lower (P=0.019).
Conclusion Both VMAT and HT can meet the radiotherapy dose requirements of oropharyngeal carcinoma. The HT plan has a better
CI, higher target dose and lower V35 of oral cavity. Although the treatment time was slightly longer, HT can reduce the incidence
of ≥3 grade radiotherapy-induced oral mucositis.
孟玲玲1，邸玉鹏2，蔡博宁1，解传滨1，巩汉顺1，赵大伟1，马林1. 口咽癌VMAT与HT的放射性口腔黏膜炎发生率及剂量学研究[J]. 中国医疗设备, 2021, 36(4): 145-148.
MENG Lingling1，DI Yupeng2，CAI Boning1，XIE Chuanbin1，GONG Hanshun1，ZHAO Dawei1，MA Lin1. Incidence and Dosimetry Comparison of Radiotherapy-induced Oral Mucositis in Patients
with Oropharyngeal Carcinoma Treated with VMAT and HT. China Medical Devices, 2021, 36(4): 145-148.
