Abstract：Objective To describe CT features and tumor cell differentiation in pathology in adenocarcinoma of lung in young patients. Methods The clinical data and CT findings of lung adenocarcinoma proved pathologically in 57 young patients were reviewed. Results The average duration from symptom onset to diagnosis was (3.6±0.4) months. 16 cases were misdiagnosed. There were 4 patients with central bronchogenic carcinoma, 52 with peripheral bronchogenic carcinoma, 1 with diffuse bronchial carcinoma (DBC) and 2 with multiple primary bronchial carcinomas (MPBC), 46 cases presented as masses and nodules and 39 with lobulation, 29 with speculation and 27 with pleural indentation. There were 51 patients with discernible degree of cancer differentiation, 1 case with AIS, 1 with minimally invasive adenocarcinoma, among invasive adenocarcinoma, 4 with high differentiation, 2 with high-moderate differentiation, 14 with moderate differentiation, 9 with low-moderate differentiation and 20 with low differentiation. Most of the cases were advanced stage when diagnosed, 44 presented with metastasis, 38 patients with chest metastasis, pleural effusion occurred in 14 patients. Conclusion Peripheral mass and nodule are the predominant CT features of lung adenocarcinoma in young patients. Poor-differentiated tumor with metastasis is common when diagnosed.
景瑞，赵绍宏，蔡祖龙，金鑫，吴芳，吴坚，吴重重. 青年肺腺癌患者CT影像特点及病理[J]. 中国医疗设备, 2014, 29(5): 157-160.
JING Rui, ZHAO Shao-hong, CAI Zu-long, JIN Xin, WU Fang, WU Jian, WU Chong-chong. CT Features and Pathology of Adenocarcinoma of Lung in Young Patients. China Medical Devices, 2014, 29(5): 157-160.
Bourke W,Milstein D,Giura R,et al.Lung cancer in young adults[J].Chest,1992,102(6):1723-1729.
[2]
Liu NS,Spitz MR,Kemp BL,et al.Adenocarcinoma of the lung in young patients-The M.D.Anderson experience[J].Cancer,2000,88(8):1837-1841.
[3]
Skarin AT,Herbst RS,Leong TL,et al.Lung cancer in patients under age 40[J].Lung Cancer,2001,32(3):255-264.
[1]
Kozielski J,Kaczmarczyk G,Porebska I,et al.Lung cancer in patients under the age of 40 years[J].Wspolczesna Onkologia-Contemporary Oncology, 2012,16(5):413-415.
[5]
Koike T,Yamato Y,Yoshiya K,et al.Predictive Risk Factors for Mediastinal Lymph Node Metastasis in Clinical Stage IA Non-Small-Cell Lung Cancer Patients[J].Journal of Thoracic Oncology,2012,7(8):1246-1251.
[7]
Bryant AS,Cerfolio RJ.Differences in outcomes between younger and older patients with non-small cell lung cancer[J]. Annals of Thoracic Surgery,2008,85(5):1735-1739.
[6]
Kuo CW,Chem YM,Chao JY,et al.Non-small cell lung cancer in very young and very old patients[J].Chest,2000,117(2):354-357.
