Dosimetric Study of the Deformable Image Registration Based on
Dose Accumulation in Adaptive Radiation Therapy
WANG Lin-jing, ZHANG Shu-xu,
LEI Huai-yu, TAN Jian-ming,
ZHANG Guo-qian,
WANG Rui-hao
Radiotherapy Center, Cancer Center of
Guangzhou Medical University, Affiliated
Tumor Hospital of Guangzhou Medical
University, Guangzhou Guangdong
510095, China
Abstract：Objective To compare and evaluate the dosimetric difference of adaptive radiation therapy
(ART) over conventional intensity modulated radiation therapy (IMRT) and 3D conformable radiation
therapy (3D-CRT) when using hybrid deformable image registration (DIR) for dose accumulation in
thoracic and pelvic cancer patients. Methods CT images of 10 lung cancer patients and 6 cervical cancer
patients who received radiation therapy were obtained for twenty treatment fractions. Then, the ART
plan was generated by applying the hybrid DIR to register the fractional and planning CT images to
calculate the accumulative dose distribution. Dosimetric parameters of the tumor and the organs at risk
(OARs) such as lungs, spinal cord, bladder and rectum were compared with the ART and the conventional
3D-CRT and IMRT plan. Results The CI and HI values in ART plan were statistically significantly
(P<0.05) better than the 3D-CRT and IMRT plans. The D95, D98, the lung V20, V30, Dmean, the heart V30, V40,
the spinal cord Dmax, the bladder V30, V40, V50, Dmean and the rectum V40, V45, V50, Dmean were all smaller
than those in 3D-CRT and IMRT plans (P<0.05). While the intestine V40, Dmean and the caput femoris V40,
Dmean decreased in ART plan, but the difference was not statistically significant. Conclusion Replanning
after 20 times can achieve better target coverage and OARs sparing, it can potentially reduce the radiation
side effect and increase the local control rate in thoracic and pelvic cancer patients.
王琳婧，张书旭，雷怀宇，
谭剑明，张国前，王锐濠. 基于形变配准剂量累加法的自适应放疗剂量学研究[J]. 中国医疗设备, 2017, 32(7): 68-73.
WANG Lin-jing, ZHANG Shu-xu,
LEI Huai-yu, TAN Jian-ming,
ZHANG Guo-qian,
WANG Rui-hao. Dosimetric Study of the Deformable Image Registration Based on
Dose Accumulation in Adaptive Radiation Therapy. China Medical Devices, 2017, 32(7): 68-73.
