Transparent Tissue-Mimicking Phantom for Evaluating Effect of Alkali
Metal Hyperthermia
YANG Peng-fei1, WANG Qian2,CHEN Bo-wei2, SHENG Lei2,LIU Jing2,3
1.Center for Medical Device Evaluation,
China Food and Drug Administration,
Beijing 100044, China; 2.Technical Institute
of Physics and Chemistry, Chinese Academy
of Science, Beijing 100190, China;
3.Department
of Biomedical Engineering,
School of Medicine, Tsinghua University,
Beijing 100084, China
Abstract：The method of alkali metal hyperthermia is rather unique in tumor ablation. Its basic principle
is to produce a strong exothermic chemical reaction through the injection of trace alkali metals such as
sodium, potassium or its alloy fluid by using the natural water environment in the target tissues, so as
to achieve the goal of efficient directional thermal ablation. For the reason that the alkali metal ablation
combines the advantages of thermal ablation and chemical ablation together, therefore, how to evaluate
its ablation effect is a subject worth to be studied. So far, it is difficult to evaluate such double effects
of ablation with nonstandard
biological tissues, for example, the use of liver tissue in vitro is very
rare among the chemical ablation effect. Therefore, it is very important to establish a standardized and
transparent phantom. This article mainly studied a kind of tissue transparent phantom for evaluating
the properties of alkali metal hyperthermia. Such phantom was mainly mixed by polyacrylamide gel
composition, egg white as a temperature sensitive indicator and phenolphthalein as the chemical sensitive
indicator. The preliminary experimental results showed that this model can be used to evaluate the
hyperthermia and chemotherapy effects of alkali metal ablation, and laid a foundation for further studying
the heat release amount, diffusion properties of reaction product, the process of the fluid transport in
biological tissues, as well as the ablation dose factors that affect the alkali metal treatment process.
杨鹏飞1，王倩2，陈柏炜2，盛磊2，刘静2,3. 一种用于碱金属流体热疗性能评价的仿组织透明体模[J]. 中国医疗设备, 2017, 32(3): 14-17.
YANG Peng-fei1, WANG Qian2,CHEN Bo-wei2, SHENG Lei2,LIU Jing2,3. Transparent Tissue-Mimicking Phantom for Evaluating Effect of Alkali
Metal Hyperthermia. China Medical Devices, 2017, 32(3): 14-17.
