Abstract:Objective To observe the clinical efficacy and safety of combination of application of MVA
(Micro-Wave Ablation) and image-guided radiotherapy in treatment of Stage IIA NSCLC (Non-Small
Cell Cancer) patients. Methods Altogether 36 patients (36 tumors) with Stage IIA NSCLC who were
treated in the hospital from February 2009 to February 2015 and unsuitable for or rejected surgical
operation were selected and underwent cool-circulation MVA under the guidance of CT. And
then, they accepted sequential radiotherapy 7 days after ablation treatment. Strengthened CT was
used to observe the preoperative and postoperative local necrosis rate of tumors. Additionally, the
disease progression time and survival time were followed up; and the incidence of intraoperative and
postoperative adverse events and treatment and prognosis were also observed. Results The postoperative
CT findings included visible gasification in the ablation area as well as the blurred tumor boundary and
glass-like changes in the lung window. Among 36 tumors, the complete necrosis rate was 88.9% (32/36);
the incomplete necrosis rate was 11.1% (4/36). After 3, 6 and 12-months followed-up, the tumor size
was gradually reduced and the average reduction rate was (8.2±6.1)%, (34.1±7.4)% and (52.6±8.3)%.
The postoperative survival rates in 1, 2 and 3 years were 83.3% (30/36), 58.3 (21/36) and 38.9% (14/36)
respectively. There were no serious intraoperative and postoperative complications. Conclusion CTguided
MVA combined with radiotherapy demonstrated its good local control effect and a high 3-year
survival rate in the treatment of Stage IIA NSCLC, which suited the patients who were unsuitable for or
rejected surgical operation .
冯庆亮,董林,李永杰. 微波消融联合放疗治疗IIA期非小细胞肺癌的疗效研究[J]. 中国医疗设备, 2016, 31(10): 110-113.
FENG Qing-liang, DONG Lin,
LI Yong-jie. Study on the Efficacy of Combination of Microwave Ablation and Radiotherapy
in the Treatment of Stage IIA Non-Small Cell Lung Cancer. China Medical Devices, 2016, 31(10): 110-113.