Abstract:Objective To investigate the dynamic contrast-enhanced MR imaging (DCE-MRI) and
diffusion-weighted imaging (DWI) features of Her-2 over expression subtype of breast cancers.
Methods Altogether 18 cases of Her-2 over expression subtype of breast cancers and 36 cases of breast
cancer without Her-2 over expression confirmed pathologically in the hospital were collected. All the
cases were examined by using 3.0T DCE-MRI and DWI. The DCE-MRI and DWI features of Her-2
over expression subtype of breast cancer were recorded and analyzed. Results Among 18 cases of Her-
2 over expression subtype of breast cancer, the speculated margin signs took up 61.1% (11/18); postenhanced
heterogeneous enhancement signs accounted for 55.6% (10/18); there were 44.4% (8/18)
lesions with lymph node metastasis. Statistically significant differences were seen between the margin,
the way of enhancement and lymph node metastasis of the Her-2 over expression breast cancer and the
breast cancer without Her-2 over expression (P<0.05). When the b value was 400, 800 and 1000 s/mm2,
the ADC value of the Her-2 over expression subtype breast cancers were (1.498±0.23) ×10-3,
(1.317±0.21)×10-3 , (1.232±0.19)×10-3 mm2/s, and the ADC value of the breast cancers without Her-2 over
expression were (1.234±0.28)×10-3, (1.053±0.25)×10-3, (0.944±0.21)×10-3 mm2/s. When the b value
was 800 s/mm2, there was statistically significant difference between the Her-2 over expression type breast
cancers and the breast cancer without Her-2 over expression (P<0.05). Conclusion DCE-MRI features
such as the speculated margin signs, heterogeneous enhancement and the ADC values were useful for
the diagnosis of Her-2 over expression subtype breast cancer. The lymph node metastases were more
frequently found in Her-2 over expression subtype breast cancer.
李逢芳,陈慧铀,王丽萍. Her-2过表达型乳腺癌磁共振-扩散加权成像及动态增强成像分析[J]. 中国医疗设备, 2016, 31(10): 51-54.
LI Feng-fang, CHEN Hui-you,
WANG Li-ping. Diffusion Weighted Imaging and Dynamic Contrast-Enhanced MR Imaging
Features of Her-2 Over Expression Subtype of Breast Cancer. China Medical Devices, 2016, 31(10): 51-54.