Screening of Differentially Expressed Genes of COPD Based on Combined Strategy
HUA Lin1, XIA Hong1, ZHOU Ping1, AN Li2
1.a.School of Biomedical Engineering; b.Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China; 2.Respiratory Medicine Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Abstract：Objective To screen differentially expressed genes of chronic obstructive pulmonary disease (COPD) through combined strategy. Methods Significance analysis of microarrays (SAM) was used to extract the differentially expressed genes of COPD from GEO database, which then were screened through five kinds of genetic sort algorithms. Then stochastic disturbance analysis and function enrichment analysis of the screened genes were conducted. Results GON4L and P4HB were important genes related to COPD. Conclusion The recognition accuracy of susceptibility genes of COPD has been improved with the application of combined strategy.
华琳，夏翃，周萍，安立. 基于组合策略的慢性阻塞性肺疾病的差异表达基因的筛选[J]. 中国医疗设备, 2014, 29(7): 133-136.
HUA Lin, XIA Hong, ZHOU Ping, AN Li. Screening of Differentially Expressed Genes of COPD Based on Combined Strategy. China Medical Devices, 2014, 29(7): 133-136.
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