Abstract：Objective To investigate the relationship between magnetic resonance microscopy (MRM)
T2 map associated with Aβ plaques and their histology on dual transgenic PS/APP mouse brain.
Methods The paper proposed an efficient, automated image-processing pipeline that used unstained
sections to reconstruct a 3D brain model from 2D histological sections and further registered these with
the corresponding 3D MRM. The imaging registration was a multistep registration procedure that first
aligned the neighboring 2D slices and then iteratively performed 2D and 3D registration. Results The
registration pipeline can accurately register the 2D histology sections and 3D MRM. Some Aβ plaques
can be found both in stained histology and MRM. Conclusion This research monitored the Aβ plaques
in PS/APP transgenic mice through neuroimaging technology, which can facilitate the understanding of
the generation, deposition, and removal of Aβ plaques in Alzheimer’s disease.
林岚，付振荣，张柏雯，
周著黄，高宏建，吴水才. PS/APP双转基因小鼠大脑中β-淀粉样
蛋白的磁共振显微成像和组织切片研究[J]. 中国医疗设备, 2016, 31(2): 31-33.
LIN Lan, FU Zhen-rong,
ZHANG Bai-wen,
ZHOU Zhu-huang,
GAO Hong-jian, WU Shui-cai. Research of Magnetic Resonance Microscopy and Histological Section
on Beta-Amyloid Plaques in PS/APP Transgenic Mice. China Medical Devices, 2016, 31(2): 31-33.
