Research on Clinical CT Scanning Conditions in the Experiment of Iodinated Oil Nanoemulsion Contrast Agents in Mice
YU Xiao-li1a, WANG Ting1b, CHEN Gong1b,2
1.a.Department of Radiology; b.Department
of Information Engineering, Affiliated
Hospital of Nanjing University of Traditional
Chinese Medicine, Nanjing Jiangsu 210029,
China; 2.State Key Laboratory of Bioelectronics,
Southeast University, Nanjing Jiangsu
210096, China
Abstract：Objective To study clinical CT scanning conditions that are most suitable for the experiment of iodinated oil nanoemulsion dual-modal contrast agents in mice. Methods Mice were subjected to multiple scanning by adjusting tube voltage, tube current and slice thickness of CT. Images of liver in different scanning conditions were observed and evaluated by using double blind method. Results The best scan condition was gained: tube voltage 80 kV, tube current 100 mAs, slice thickness 1 mm. Conclusion On this condition, mice were scanned after injection of iodine oil nanoemulsion dual-modal contrast agents, and enhanced images of mice were improved effectively. The best scanning condition can meet the requirements of the experiment of Iodinated oil nanoemulsion contrast agents in mice.
于小利，王婷，陈功. 小鼠碘油纳米乳造影剂实验临床CT扫描条件的研究[J]. 中国医疗设备, 2015, 30(11): 29-31.
YU Xiao-li, WANG Ting, CHEN Gong. Research on Clinical CT Scanning Conditions in the Experiment of Iodinated Oil Nanoemulsion Contrast Agents in Mice. China Medical Devices, 2015, 30(11): 29-31.
de Krafft KE,Xie Z,Cao G,et al.Iodinated nanoscale coordination polymers as potential contrast agents for computed tomography[J].Angew Chem Int Ed,2009,48:9901-9904.
[10]
Gomes CM,Abrunhosa AJ,Ramos P,et al.Molecular imaging with SPECT as a tool for drug development[J].Adv Drug Deliv Rev,2011,63(7):547-554.
[1]
Kong WH,Lee WJ,Cui ZY,et al.Nanoparticulate carrier containing water-insoluble iodinated oil as a multifunctional contrast agent for computed tomography imaging[J].Biomaterials,2007,28:5555-5561.
[1]
Kong WH,Lee WJ,Cui ZY,et al.Nanoparticulate carrier containing water-insoluble iodinated oil as a multifunctional contrast agent for computed tomography imaging[J].Biomaterials,2007,28:5555-5561.
[2]
de Krafft KE,Xie Z,Cao G,et al.Iodinated nanoscale coordination polymers as potential contrast agents for computed tomography[J].Angew Chem Int Ed,2009,48:9901-9904.
[3]
Krause W.Delivery of diagnostic agents in computed tomography[J].Adv Drug Delivery Rev,1999,37:159-173.
[7]
Hedvig H.Advancing molecular imaging:A chairman’s perspective on how radiology can meet the challenge[J].Pediatr Radiol,2011,41:141-143.
[3]
Krause W.Delivery of diagnostic agents in computed tomography[J].Adv Drug Delivery Rev,1999,37:159-173.
[6]
Simberg D,Duza T,Park JH,et al.Biomimetic amplification of nanoparticle homing to tumors[J].PNAS,2007,104:932-936.
[7]
Hedvig H.Advancing molecular imaging:A chairman’s perspective on how radiology can meet the challenge[J].Pediatr Radiol,2011,41:141-143.
[5]
Bryson JM,Fichter KM,Chu WJ,et al.Polymer beacons for luminescence and magnetic resonance imaging of DNA delivery[J].PNAS,2009,106:16913-16918.
[2]
de Krafft KE,Xie Z,Cao G,et al.Iodinated nanoscale coordination polymers as potential contrast agents for computed tomography[J].Angew Chem Int Ed,2009,48:9901-9904.
[8]
Weissleder R.Molecular imaging in cancer[J].Science,2006, 312(5777):1168-1171.
[8]
Weissleder R.Molecular imaging in cancer[J].Science,2006, 312(5777):1168-1171.
Kong WH,Lee WJ,Cui ZY,et al.Nanoparticulate carrier containing water-insoluble iodinated oil as a multifunctional contrast agent for computed tomography imaging[J].Biomaterials,2007,28:5555-5561.
[4]
Atanasijevic T,Shusteff M,Fam P,et al.Calciumsensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin[J].PNAS,2006,103:14707-14712.
[4]
Atanasijevic T,Shusteff M,Fam P,et al.Calciumsensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin[J].PNAS,2006,103:14707-14712.
[5]
Bryson JM,Fichter KM,Chu WJ,et al.Polymer beacons for luminescence and magnetic resonance imaging of DNA delivery[J].PNAS,2009,106:16913-16918.
[6]
Simberg D,Duza T,Park JH,et al.Biomimetic amplification of nanoparticle homing to tumors[J].PNAS,2007,104:932-936.
[6]
Simberg D,Duza T,Park JH,et al.Biomimetic amplification of nanoparticle homing to tumors[J].PNAS,2007,104:932-936.
[9]
Cheon J,Lee JH.Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology[J].Acc Chem Res,2008,41(12):1630-1640.
[9]
Cheon J,Lee JH.Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology[J].Acc Chem Res,2008,41(12):1630-1640.
Atanasijevic T,Shusteff M,Fam P,et al.Calciumsensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin[J].PNAS,2006,103:14707-14712.
[5]
Bryson JM,Fichter KM,Chu WJ,et al.Polymer beacons for luminescence and magnetic resonance imaging of DNA delivery[J].PNAS,2009,106:16913-16918.
[9]
Cheon J,Lee JH.Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology[J].Acc Chem Res,2008,41(12):1630-1640.
[10]
Gomes CM,Abrunhosa AJ,Ramos P,et al.Molecular imaging with SPECT as a tool for drug development[J].Adv Drug Deliv Rev,2011,63(7):547-554.
[10]
Gomes CM,Abrunhosa AJ,Ramos P,et al.Molecular imaging with SPECT as a tool for drug development[J].Adv Drug Deliv Rev,2011,63(7):547-554.
[12]
Gianella A,Jarzyna PA,Mani V,et al.Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer[J].ACS Nano,2011,5(6):4422-4433.
[12]
Gianella A,Jarzyna PA,Mani V,et al.Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer[J].ACS Nano,2011,5(6):4422-4433.
[12]
Gianella A,Jarzyna PA,Mani V,et al.Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer[J].ACS Nano,2011,5(6):4422-4433.
