Application Value of Combination Value of Micro-RNA and PET-CT in Diagnosis of Postoperative Metastasis of Head and Neck Squamous Cell Cancers
XU Tonga, YAN Hui-lib, XU Tingc
a. Department of Otolaryngology; b. Department of Endocrinology; c. Department of Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan Shandong 250021, China
Abstract：Objective To discuss the application value of positron emission tomography/computed tomography (PET/CT) and micro-RNA in diagnosis of post-operative metastasis of head and neck squamous cell cancers. Methods Altogether 40 patients with surgical history of head and neck cancer simultaneously underwent the examination of PET/CT in combination with a micro-RNA kit that was comprised four micro-RNAs. The results were compared with the final diagnosis so as to analyze the sensitivity, specificity and accuracy of these two diagnosis methods. Results Of those 40 cases, 28 were found with metastases of head and neck squamous cell carcinoma as was diagnosed pathologically. The sensitivity, specificity and accuracy of the micro-RNA kit for diagnosis of metastasis were 96.43%, 83.33% and 92.50%. While, those of PET/CT were 89.29%, 91.67% and 90.00%, respectively. Promisingly, those by the detection of PET/CT combined with the micro-RNA kit were 100%, 83.33% and 95.00%. Conclusion PET/CT showed higher specificity and lower sensitivity in assessment of postoperative metastasis of head and neck cancers than those by the micro-RNA kit. The micro-RNA kit detection may be used as a supplementary tool to PET/CT examination. Combined use of the two examinations was an ideal strategy for detecting the metastases of head and neck cancers.
许彤，阎慧丽，许挺. microRNA联合PET-CT对头颈部鳞状细胞癌术后转移的诊断价值[J]. 中国医疗设备, 2015, 30(10): 51-54.
XU Tong, YAN Hui-li, XU Ting. Application Value of Combination Value of Micro-RNA and PET-CT in Diagnosis of Postoperative Metastasis of Head and Neck Squamous Cell Cancers. China Medical Devices, 2015, 30(10): 51-54.
